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KMID : 1149220160240040283
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Korean Journal of Oriental Medical Prescription
2016 Volume.24 No. 4 p.283 ~ p.288
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Inhibitory effect of Rhus verniciflua Stokes extract in MCF-7 human breast cancer cells
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Kim Min-Sung
An Won-Gun
Lee Jang-Cheon
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Abstract
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Objectives : The purpose of this study was to investigate the anti-cancer effects of extract of Rhus verniciflua Stokes (RVS) in human breast cancer cell lines.
Methods : In cultured human breast cancer MCF-7 cells, we investigated growth inhibitory effect of RVS. MCF-7 cells were cultured with various concentrations (0, 200, 300, and 400 ug/ml) of RVS at 37oC for 24 h. We performed CCK-8 assay and flow cytometry for detection of Annexin V-PI staining.
Results : As a result, RVS inhibits the cell growth and induction of apoptosis in dose dependent manner in MCF-7 breast cancer cells.
Conclusion : RVS has anti-cancer activities and induced apoptosis in human breast cancer MCF-7 cells. Therefore we suggest that RVS can use as a novel class of anti-cancer drugs.
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KEYWORD
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Rhus verniciflua Stokes , human breast cancer MCF-7 cells , apoptosis
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